Five fire engines from Rotherham, Elm Lane, Parkway and Central stations were called to an industrial premise at 1:50 am on Saturday morning.
On arrival firefighters found the garage repair centre on Clough Road in Masbrough, Rotherham well alight with a number of cars inside the premise.
Firefighters wearing breathing apparatus used hose reels to tackle the fire.
A small number of cars were destroyed or damaged in the incident.
An investigation into the cause of the fire will now take place.