Four fire crews from Rivelin, Central and Elm Lane stations were called to a farmhouse on Spout Lane in the Stannington area of Sheffield at 3:10am on Monday morning.
When firefighters arrived at the scene the farmhouse was well alight.
The fire is currently under control and crews are damping down at the scene.
An investigation into the cause of the fire will take place once the fire is completely out.
Further updates will be issued shortly.