Three fire engines from Parkway, Central and Elm Lane stations were called to a car repair centre on Coleford Road in Sheffield just before 1:30 am on Tuesday morning.
On arrival fire crews found a number of cars and vans on fire.
Firefighters wearing breathing apparatus used main jets to tackle the blaze.
Fire crews left the scene at 4:45 am.
An investigation into the cause of the fire will now take place.