Firefighters were called to a block of flats at North Bank in Sheffield just after 6:30am on Tuesday morning.
Six fire crews from Central, Parkway, Rivelin, Elm Lane and Birley Moor stations attended the incident.
The small fire was on a corridor on the sixth floor. Two people were already outside the flats when crews arrived.
A turntable ladder was used to rescue two people from the sixth floor.
Firefighters wearing breathing apparatus quickly extinguished the fire which was contained in the corridor area.
Following an initial fire investigation the fire is believed to have been started deliberately.